Search results for " NF-κB signaling pathway as hub of inflammatory ageing network"

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NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies

2013

Chronic inflammation is a major biological mechanism underpinning biological ageing process and age-related diseases. Inflammation is also the key response of host defense against pathogens and tissue injury. Current opinion sustains that during evolution the host defense and ageing process have become linked together. Thus, the large array of defense factors and mechanisms linked to the NF-κB system seem to be involved in ageing process. This concept leads us in proposing inductors of NF-κB signaling pathway as potential ageing biomarkers. On the other hand, ageing biomarkers, represented by biological indicators and selected through apposite criteria, should help to characterize biologica…

AgingBiological ageInflammatory network and its effects in ageingImmunologyLarge arrayReviewWorking hypothesisBiological ageing processchemistry.chemical_compoundBiological ageing process Inflammatory network and its effects in ageing NF-κB signaling pathway as hub of inflammatory ageing network Inflammatory biomarkersSettore MED/05 - Patologia ClinicaMedicineSettore MED/04 - Patologia Generalebusiness.industryMechanism (biology)NF-κBInflammatory biomarkersRisk factor (computing)NF-κB signaling pathway as hub of inflammatory ageing networkInflammatory biomarkersAgeingchemistryAgeingImmunologybusinessNeuroscienceImmunity & Ageing
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